Adult-type hypolactasia and lactose malabsorption in Poland.

Adult-type hypolactasia and lactose malabsorption in Poland.

BACKGROUND The available data on the incidence of lactose malabsorption are contradictory. Potential bias in random selection is a major drawback of studies performed to-date. Moreover, molecular analysis of polymorphism -13910 C>T upstream of the lactase (LCT) gene (NM_005915.4:c.1917+326C>T; rs4988235) has not been reported in those studies. Therefore, in this study we aimed to assess genetic...

Hypolactasia: a common enzyme deficiency leading to lactose malabsorption and intolerance.

Adult‑type hypolactasia (lactase nonpersistence or lactase deficiency) is the most common enzyme deficiency leading to lactose intolerance and primary lactose malabsorption. Clinical presentation of the condition includes symptoms resulting from bacterial fermentation of undigested lactose in the colon, which gives rise to gas bloat, increased motility, and loose stools. Diagnosis of the diseas...

Lactose malabsorption and nutrition

© 2014 John Wiley & Sons, Ltd. Published 2014 by John Wiley & Sons, Ltd. The consumption of milk and dairy products varies considerably in different regions of the world. Indeed, according to the statistics of the Food and Agriculture Organization of the United Nations (FAO), in 2007 the consumption of milk and dairy products averaged 240 kg and 360 kg per capita in the UK and Sweden, respectiv...

ADULT-TYPE HYPOLACTASIA: Genotype-phenotype correlation

Genetic Aspects of Adult-Type Hypolactasia

Background and objective: Lactose is a disaccharide sugar and is found in mammals milk and derivatives. Lactose intolerance is the inability to metabolize lactose, because of a lack of the required enzyme lactase in the digestive system. Genetically the physiological hypolactasia (primary LM) is associated with the LCT-13910 C/T and LCT-22018 G/A polymorphisms. The aim of this study focused on ...